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Title   Cisplatin 병합화학요법시 급성 항구토효과에 대한 Tropisetron 과 Ondansetron 의 비교 ( A Comparison of the Acute Antiemetic Effect of Tropisetron with Ondansetron in Patients Receiving Cisplatin )
Publicationinfo   1998 Jan; 030(06): 1240-1249.
Key_word   Tropisetron, Ondansetron, Cisplatin, Emesis
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Abstract   Purpose: Tropisetron, a new specific 5-hydroxytryptamine3 (5-HT) receptor antagonist, is an effective antiemetic agent in the control of chemotherapy induced emesis with a long half life and bioavailablity. We compared the efficacy and safefy of Tropisetron and ondansetron to control emesis induced by highly emetogenic chemotherapeutics (cisplatin >= 50 mg/m(2)). Materials and Methods: Twenty-one patients were administered in a randomized, open, crossover study and received either tropisetron plus dexamethasone or ondansetron plus dexamethasone during two successive cycles of chemotherapy. Results: Control of acute emesis with either tropisetron or ondansetron was 100% vs 95.2%, and 80.9% vs 76.2% in control of delayed emesis. Both severity and duration of nausea showed no statistically significant difference between tropisetron and ondansetron. Poor appetite and headache were most common side effects in both groups. Conclusion: There was no significant difference in efficacy for control of emesis and nausea between tropisetron and ondansetron in cisplatin-based chemotherapy.
저 자   조성태(Sung Tae Cho),황보권(Bo Kwon Hwang),김찬규(Chan Kyu Kim),고봉민(Bong Min Ko),배성한(Sung Han Bae),봉종대(Jong Dae Bong),이철우(Cheol Woo Lee),박성ㄱ(Sung Kyu Park),원종호(Jong Ho Won),백승호(Seung Ho Baick),홍대식(Dae Sik Hong),박희숙(Hee Sook Park)